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	<title>Diabetes, Thyroid, Adrenal, Pituitary, Steroid, Calcium and other Hormonal disorders &#124; Dr Arpan Bhattacharyya &#187; Diabetes</title>
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	<link>http://www.diabetesendocrinology.in</link>
	<description>This portal is about diabetes, thyroid, Steroid and other common clinical problems in relation to the field of Diabetes and Endocrinology.</description>
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		<title>Diabetes management in Hospitalized patients – 2009</title>
		<link>http://www.diabetesendocrinology.in/2010/08/18/diabetes-hospital-protocol/</link>
		<comments>http://www.diabetesendocrinology.in/2010/08/18/diabetes-hospital-protocol/#comments</comments>
		<pubDate>Wed, 18 Aug 2010 11:48:39 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Diabetes Hospital Protocol]]></category>

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		<description><![CDATA[Patient Identification 1) Name………………………. 2) Age………. 3) Sex………….. 4) Hospital no……………… 5) Date ………………..…. Known diabetic (Type 1 / Type 2 / others) New diagnosis of high sugar…………….. Existing treatment of Diabetes mellitus 1) Diet only…………. 2) Oral Diabetes tablets…………. 3) Insulin and tablets…………… 4) Insulin only……………… Control of diabetes 1) Sugar on admission (Glucometer) [...]]]></description>
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<p><span style="font-size: medium;">Patient Identification</span></p>
<p>1)  Name……………………….</p>
<p>2)  Age……….</p>
<p>3)  Sex…………..</p>
<p>4)  Hospital no………………</p>
<p>5)  Date ………………..….</p>
<p><span style="font-size: medium;">Known diabetic (Type 1 / Type 2 / others)</span></p>
<p><span style="font-size: medium;">New diagnosis of high sugar……………..</span></p>
<p lang="en-IN">
<p><span style="font-size: medium;">Existing treatment of Diabetes mellitus </span></p>
<p>1)  Diet only………….</p>
<p>2)  Oral Diabetes tablets………….</p>
<p>3)  Insulin and tablets……………</p>
<p>4)  Insulin only………………</p>
<p><span style="font-size: medium;">Control of diabetes</span></p>
<p>1)  Sugar on admission (Glucometer) …..</p>
<p>2) 1<sup>st</sup> lab sugar -</p>
<p>3)  HbA1C (if available)….</p>
<p><span style="font-size: medium;"><em><strong>Whom to Inform</strong></em></span></p>
<table border="1" cellspacing="0" cellpadding="7" width="591" bordercolor="#000000">
<col width="160"></col>
<col width="401"></col>
<tbody>
<tr valign="TOP">
<td width="160">Diabetes Helpline</td>
<td width="401">On rotation Specialist Registrar &#8211; 9845502220</td>
</tr>
<tr valign="TOP">
<td width="160">Consultant</td>
<td width="401">Dr A Bhattacharyya &#8211; 9886051410</td>
</tr>
</tbody>
</table>
<p><span style="font-size: medium;"><strong>Important</strong></span><span style="font-size: medium;"> </span><span style="font-size: medium;"><strong>notes</strong></span></p>
<p><span style="font-size: medium;"><em>Any sugar value more than 350mg, please check urine for ketone and blood for Bicarbonates.</em></span></p>
<p><!-- 		@page { margin: 2cm } 		P { margin-bottom: 0.21cm } --></p>
<p style="text-align: center;"><span style="font-size: medium;"><strong> PROTOCOL </strong></span></p>
<p><span style="font-size: medium;"><strong>Frequency of blood sugar monitoring by Glucometer</strong></span></p>
<p><span style="font-size: medium;">1) On I.V Insulin<br />
</span></p>
<p>2 hrly acceptable, 1hrly if sugar fluctuating too much, 4 hrly if sugar is stable     in the same flow rate for 3 consecutive readings</p>
<p><span style="font-size: medium;">2) On GIK Regimen<br />
</span></p>
<p><span style="font-size: medium;"> 4</span><sup><span style="font-size: medium;">th</span></sup><span style="font-size: medium;"> hourly</span></p>
<p><span style="font-size: medium;"><strong>3</strong></span><span style="font-size: medium;">)  On S/C insulin ( patient eating)</span></p>
<p>GRBS -3 Premeals and 3 postmeals (6 /day) initially, later to reduce.</p>
<p><span style="font-size: medium;"><strong>A. IV INSULIN</strong></span></p>
<p>1) Fluid to 	infuse- 5% DNS preferably, if hypertensive 5% D1/2 NS or 5% D</p>
<p><!-- 		@page { margin: 2cm } 		P { margin-bottom: 0.21cm } -->2)  Rate of infusion as per clinical requirement.</p>
<p>3)  To add KCl 10mmol in each bottle unless proved otherwise.</p>
<p><strong>INSULIN</strong></p>
<p>( 50 units of short acting insulin – Actrapid <strong>/</strong> Huminsulin- R <strong>/</strong> Novorapid <strong>/</strong> Humalog            in 50ml syringe filled with 49 ml NS )</p>
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<td width="575" valign="TOP"><span style="font-size: medium;"><strong>A)  If patient was 			on diet or new diagnosis, start with scale 1.</strong></span></p>
<p><span style="font-size: medium;"><strong>B)  If on tablet or 			insulin &lt;30 units /day start with scale 2.</strong></span></p>
<p><span style="font-size: medium;"><strong>C) Otherwise start with scale 3.</strong></span></td>
</tr>
</tbody>
</table>
<p><!-- 		@page { margin: 2cm } 		P { margin-bottom: 0.21cm } --><strong>SCALE ONE</strong></p>
<table border="1" cellspacing="0" cellpadding="7" width="533" bordercolor="#000000">
<col width="226"></col>
<col width="277"></col>
<tbody>
<tr valign="TOP">
<td width="226">GLUCOMETER SUGAR</p>
<p>(mg%)</td>
<td width="277">INSULIN (ml/hr)</td>
</tr>
<tr valign="TOP">
<td width="226">&lt;80%</td>
<td width="277">Nil</td>
</tr>
<tr valign="TOP">
<td width="226">80-110</td>
<td width="277">0.5</td>
</tr>
<tr valign="TOP">
<td width="226">111-140</td>
<td width="277">1</td>
</tr>
<tr valign="TOP">
<td width="226">141-160</td>
<td width="277">1.5</td>
</tr>
<tr valign="TOP">
<td width="226">161-200</td>
<td width="277">3 (3 consecutive readings, go to scale 2)</td>
</tr>
<tr valign="TOP">
<td width="226">&gt;200</td>
<td width="277">Go to 			scale 2</td>
</tr>
</tbody>
</table>
<p><strong>SCALE TWO </strong></p>
<table border="1" cellspacing="0" cellpadding="7" width="520" bordercolor="#000000">
<tbody>
<tr valign="TOP">
<td width="226">GLUCOMETER SUGAR (mg%)</td>
<td width="264">INSULIN (ml/hr)</td>
</tr>
<tr>
<td width="226">&lt;80</td>
<td width="264" valign="TOP">Nil (for 3 consecutive readings, scale 1)</td>
</tr>
<tr>
<td width="226">80-110</td>
<td width="264" valign="TOP">1</td>
</tr>
<tr>
<td width="226">111-140</td>
<td width="264" valign="TOP">2</td>
</tr>
<tr>
<td width="226">141-160</td>
<td width="264" valign="TOP">3</td>
</tr>
<tr>
<td width="226">161-200</td>
<td width="264" valign="TOP">6 (3 consecutive readings,↑ to 8 )</td>
</tr>
<tr>
<td width="226" height="8">201-240</td>
<td width="264" valign="TOP">8 (3 consecutive readings scale 3)</td>
</tr>
<tr>
<td width="226">&gt;240</td>
<td width="264" valign="TOP">Go to scale 3</td>
</tr>
</tbody>
</table>
<p><strong>SCALE THREE</strong></p>
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<col width="247"></col>
<col width="273"></col>
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<tr valign="TOP">
<td width="247">GLUCOMETER SUGAR</p>
<p>(mg%)</td>
<td width="273">INSULIN(ml/hr)</td>
</tr>
<tr valign="TOP">
<td width="247">For 3 consecutive readings &lt;80</td>
<td width="273">0.5(for 3 consecutive readings,scale 2)</td>
</tr>
<tr valign="TOP">
<td width="247">80-110</td>
<td width="273">1.5</td>
</tr>
<tr valign="TOP">
<td width="247">111-140</td>
<td width="273">4</td>
</tr>
<tr valign="TOP">
<td width="247">141-160</td>
<td width="273">6</td>
</tr>
<tr valign="TOP">
<td width="247">161-200</td>
<td width="273">10 ( 3 consecutive readings,↑ to 14)</td>
</tr>
<tr valign="TOP">
<td width="247">201-240</td>
<td width="273">14 ( 3 consecutive readings,↑ to 20)</td>
</tr>
<tr valign="TOP">
<td width="247">&gt;240</td>
<td width="273">20 and please inform</td>
</tr>
</tbody>
</table>
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<h4><span style="font-size: medium;">B. GIK </span><span style="font-size: medium;">REGIMEN  &#8211; </span></h4>
<p lang="da-DK">Date &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..</p>
<h4><span style="text-decoration: underline;">BASAL –</span></h4>
<h4>Daytime (8 am till 10 pm) &#8211; DNS + K+ Insulin…………………&#8230;..</h4>
<h4>Nighttime (10 pm till 8 am) – DNS + K + Insulin …………………</h4>
<p><span style="text-decoration: underline;"><strong>CORRECTIVE </strong></span> –  <em><strong>4 hourly sc Insulin</strong></em><strong> (…………..……………..)</strong></p>
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<col width="280"></col>
<col width="281"></col>
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<tr valign="TOP">
<td width="280">GLUCOMETER SUGAR (mg%)</td>
<td width="281">Insulin SC</td>
</tr>
<tr valign="TOP">
<td width="280">&lt; 100</td>
<td width="281">Please inform</td>
</tr>
<tr valign="TOP">
<td width="280">100-120</td>
<td width="281">x</td>
</tr>
<tr valign="TOP">
<td width="280">121 -140</td>
<td width="281">2</td>
</tr>
<tr valign="TOP">
<td width="280">141-160</td>
<td width="281">4</td>
</tr>
<tr valign="TOP">
<td width="280">161-200</td>
<td width="281">6</td>
</tr>
<tr valign="TOP">
<td width="280">201-240</td>
<td width="281">8</td>
</tr>
<tr valign="TOP">
<td width="280">&gt;240</td>
<td width="281">Please inform</td>
</tr>
</tbody>
</table>
<h4>GIK regimen  -</h4>
<p lang="da-DK">Date &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..</p>
<h4><span style="text-decoration: underline;">BASAL –</span></h4>
<h4>Daytime (8 am till 10 pm) &#8211; DNS + K+ Insulin…………………&#8230;..</h4>
<h4>Nighttime (10 pm till 8 am) – DNS + K + Insulin …………………</h4>
<p><span style="text-decoration: underline;"><strong>CORRECTIVE </strong></span> –  <em><strong>4 hourly sc Insulin</strong></em><strong> (…………..……………..)</strong></p>
<table border="1" cellspacing="0" cellpadding="7" width="591" bordercolor="#000000">
<col width="280"></col>
<col width="281"></col>
<tbody>
<tr valign="TOP">
<td width="280">GLUCOMETER SUGAR (mg%)</td>
<td width="281">Insulin SC</td>
</tr>
<tr valign="TOP">
<td width="280">&lt; 100</td>
<td width="281">Please inform</td>
</tr>
<tr valign="TOP">
<td width="280">100-120</td>
<td width="281">x</td>
</tr>
<tr valign="TOP">
<td width="280">121 -140</td>
<td width="281">2</td>
</tr>
<tr valign="TOP">
<td width="280">141-160</td>
<td width="281">4</td>
</tr>
<tr valign="TOP">
<td width="280">161-200</td>
<td width="281">6</td>
</tr>
<tr valign="TOP">
<td width="280">201-240</td>
<td width="281">8</td>
</tr>
<tr valign="TOP">
<td width="280">&gt;240</td>
<td width="281">Please inform</td>
</tr>
</tbody>
</table>
<h4><span style="font-size: medium;">c.</span><span style="font-size: medium;"> SC INSULIN (MULTIPLE SC INSULIN INJECTION REGIMEN)-WHEN EATING ADEQUATELY</span></h4>
<p>Switching over to sc insulin &#8211; to switch over when eating adequately, preferred regimen basal bolus regimen (3 premeal short acting insulin and one bedtime longer acting insulin) to start with an overlap of 30min with iv insulin</p>
<p lang="en-IN">
<p><span style="font-size: medium;"><em><strong>Please 	inform PREMEAL &lt;100 &gt;140, POSTMEAL  &lt;120 &gt;180 mg/dl</strong></em></span></p>
<dl>
<dd>
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<td rowspan="2" width="45" height="31">Date</td>
<td rowspan="2" width="46">Time</td>
<td rowspan="2" width="46">GRBS</td>
<td rowspan="2" width="130">Insulin name</td>
<td colspan="2" width="106">Dose</td>
<td rowspan="2" width="46">Route</td>
<td rowspan="2" width="46">Sign</td>
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<td rowspan="2" width="45" height="31">Date</td>
<td rowspan="2" width="46">Time</td>
<td rowspan="2" width="46">GRBS</td>
<td rowspan="2" width="130">Insulin name</td>
<td colspan="2" width="106">Dose</td>
<td rowspan="2" width="46">Route</td>
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</table>
</dd>
</dl>
<p><!-- 		@page { margin: 2cm } 		P { margin-bottom: 0.21cm } --><span style="font-size: medium;"><strong>Outcome</strong></span></p>
<p>1) discharged</p>
<p>2) died</p>
<p><strong> </strong></p>
<p><span style="font-size: medium;"><strong>Discharge time note</strong></span><span style="font-size: medium;"> ( to be completed by diabetes team)</span></p>
<p>1) Discharge medication for diabetes</p>
<p>a) tablet …………………………….</p>
<p>b) insulin …………………………….</p>
<ol>
<li>Diabetes control in hospital</li>
</ol>
<p>ON IV INSULIN-</p>
<ol>
<li>Duration………………..</li>
<li>Control………………….</li>
<li>Hypoglycaemia*…………………….</li>
<li>Average sugar……………</li>
</ol>
<p>ON GIK REGIMEN-</p>
<ol>
<li>Duration…………………</li>
<li>Control…………………..</li>
<li>Hypoglycaemia*……………………..</li>
<li>Average sugar…………….</li>
</ol>
<p>ON S/C INSULIN-</p>
<ol>
<li>Duration…………………</li>
<li>Control…………………..</li>
<li>Hypoglycaemia*…………………….</li>
<li>Average sugar…Fasting………</li>
</ol>
<p>Premeal……&#8230;</p>
<p>Postmeal…….</p>
<p>COMPLICATIONS</p>
<p>DKA / HONK…………</p>
<p>*Hypoglycaemia</p>
<p>Grade 1 ( mild) Sugar bet 50-60, conscious, no symptoms</p>
<p>Grade 2  ( moderate) sugar bet 40-50, conscious with symptoms</p>
<p>Grade 3 (severe) sugar less than 40, altered sensorium</p>
<p>FINAL-DIAGNOSIS…………………………………</p>
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		<title>Diabetes, Dyslipidemia and Heart Protection</title>
		<link>http://www.diabetesendocrinology.in/2010/04/25/diabetes-dyslipidemia-and-heart-protection/</link>
		<comments>http://www.diabetesendocrinology.in/2010/04/25/diabetes-dyslipidemia-and-heart-protection/#comments</comments>
		<pubDate>Sun, 25 Apr 2010 10:29:05 +0000</pubDate>
		<dc:creator>arpan</dc:creator>
				<category><![CDATA[Diabetes]]></category>
		<category><![CDATA[bad cholesterol]]></category>
		<category><![CDATA[dyslipidaemia]]></category>
		<category><![CDATA[good cholesterol]]></category>
		<category><![CDATA[heart protection]]></category>

		<guid isPermaLink="false">http://www.diabetesendocrinology.in/?p=611</guid>
		<description><![CDATA[It is important to prevent or control dyslipidemia and protect our heart. You need to follow your doctor’s recommendations for diet, exercise, and medications. Routine checkups to monitor your lipid levels will help you manage dyslipidemia. What is dyslipidemia? Cholesterol and triglycerides, known as lipids, are fatty substances normally produces by the body. Dyslipidemia means [...]]]></description>
			<content:encoded><![CDATA[<p>It is important to prevent or control dyslipidemia and protect our heart. You need to follow your doctor’s recommendations for diet, exercise, and medications. Routine checkups to monitor your lipid levels will help you manage dyslipidemia.</p>
<p><strong>What is dyslipidemia?</strong></p>
<p>Cholesterol and triglycerides, known as lipids, are fatty substances normally produces by the body. Dyslipidemia means lipid levels in the bloodstream are too high or low. The most common types of dyslipidemia are :</p>
<ul>
<li>High levels of low-denisty lipoprotein (LDL or “bad”) cholesterol</li>
<li>Low levels of high-density lipoproptein 9HDL or “good”) cholesterol</li>
<li>High levels of triglycerides</li>
</ul>
<p>Dyslipidemia contributes to atherosclerosis, a disease in which fatty deposits called plaque build up in the arteries over time. The arteries are blood vessels that carry blood from the heart to the rest of the body. If plaque narrows your arteries, you are more likely to suffer from heart disease, heart attack, peripheral artery disease (reduced blood flow in the limbs, usually the legs), and stroke.</p>
<p><strong>Why is dyslipidemia a concern for people with diabetes?</strong></p>
<p>People with diabetes are more likely to develop atherosclerosis, heart disease, poor circulation, and stroke than people who do not have diabetes. Many people with diabetes have conditions called risk factors that contribute to atherosclerosis and its complications. These include high blood pressure, excess weight, and high blood glucose (sugar) levels. Dyslipidemia further raises the risk of atherosclerosis in people with diabetes.</p>
<p>Dyslipidemia affects people with type 2 diabetes more often than those with type 1 diabetes. The most common dyslipidemia in diabetes is the combination of high triglycerides and low HDL levels People with diabetes may also have elevated LDL cholesterol.</p>
<p><strong>How will you know if you have dyslipidemia?</strong></p>
<p>Dyslipidemia has no symptoms, so the diagnosis is made by a blood test called a lipid profile. This test measures the amount of cholesterol, triglycerides, and other fats in your bloodstream.</p>
<p>Your lipid levels can be affected by age, sex, and family history. Lifestyle factors such as diet, physical activity, and smoking also affect lipid levels. High blood glucose levels may also contribute to dyslipidemia.</p>
<p><strong>What should your lipid levels be?</strong></p>
<p>Target values (desired levels of lipids) depend on your risk factors for heart disease. The more risk factors you have, the lower your target LDL level should be. The American Diabetes Association recommends the following target values for people with diabetes:</p>
<p>LDL cholesterol: below 100 mg/dL, or below 70 mg/dL for people with heart disease or atherosclerosis</p>
<p>HDL cholesterol: above 40 mg/dL for men and above 50 mg/dL for women</p>
<p>Triglycerides: below 150 mg/dL</p>
<p><strong>What can you do to improve lipid levels and keep your heart healthy?</strong></p>
<p>You can improve lipid levels with a heart healthy diet and weight loss, increased physical activity and good blood glucose control. Limiting fat intake, especially animal fats and trans fat, can lower LDL cholesterol. Adding more fruits, vegetables, and fiber to your diet also helps reduce lipid levels. You many also need medication.</p>
<p>Among the drugs available to treat dyslipidemia, statins are often the first choice for lowering total and LDL cholesterol elves. (Pregnant women should never use statins.) Other drugs that lower cholesterol include cholesterol-absorption blockers, bile acid sequestrants, and nicotinic acid. These may be used in combination if a single drug is not effective in reaching target levels. Fibrates and extended-release niacin may be used to lower triglycerides or raise HDL cholesterol levels.</p>
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		<title>Diabetes and Driving</title>
		<link>http://www.diabetesendocrinology.in/2010/02/19/diabetes-and-driving/</link>
		<comments>http://www.diabetesendocrinology.in/2010/02/19/diabetes-and-driving/#comments</comments>
		<pubDate>Fri, 19 Feb 2010 05:08:45 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Diabetes and Driving]]></category>
		<category><![CDATA[Diabetes]]></category>
		<category><![CDATA[Driving]]></category>
		<category><![CDATA[safe sugar control]]></category>

		<guid isPermaLink="false">http://www.diabetesendocrinology.in/?p=574</guid>
		<description><![CDATA[People with well-controlled diabetes are at greater risk for car crashes and other driving mishaps, according to two recent studies. Diabetes patients strive for tight control of blood sugar, aspiring for glycosylated hemoglobin (hbA1c) levels of 6.5-7. However, the methods used to stay at these levels, including regular blood tests and treatment with insulin and [...]]]></description>
			<content:encoded><![CDATA[<p><!-- 		@page { margin: 2cm } 		P { margin-bottom: 0.21cm } --></p>
<p style="margin-bottom: 0cm; font-weight: normal;" align="JUSTIFY"><span style="font-size: small;">People with well-controlled diabetes are at greater risk for car crashes and other driving mishaps, according to two recent studies.</span></p>
<p style="margin-bottom: 0cm; font-weight: normal;" align="JUSTIFY"><span style="font-size: small;">Diabetes patients strive for tight control of blood sugar, aspiring for glycosylated hemoglobin (hbA1c) levels of 6.5-7. However, the methods used to stay at these levels, including regular blood tests and treatment with insulin and drugs can cause episodes of hypoglycemia, leading patients to lose concentration or even consciousness.</span></p>
<p style="margin-bottom: 0cm; font-weight: normal;" align="JUSTIFY">
<p style="margin-bottom: 0cm; font-weight: normal;" align="JUSTIFY"><span style="font-size: small;">One 2-year study in the Public Library of Science compared the Hba1c levels of 795 drivers with diabetes who had or hadn’t been in an accident. The researchers found that lower HbA1c levels were tied to a higher risk of a motor vehicle crash. Those in previous accidents had an average HbA1c level of 7.4, compared with 7.9 among those who had not. The authors claim that the increase risk of lower HbA1c might account for about one-third of the 57 accidents in the study.</span></p>
<p style="margin-bottom: 0cm; font-weight: normal;" align="JUSTIFY">
<p style="margin-bottom: 0cm; font-weight: normal;" align="JUSTIFY"><span style="font-size: small;">A 1-year study in Diabetes Care screened 452 drivers with type 1 diabetes for mishaps such as collisions, citations, and losing control, as ell as self-reported hypoglycemic episodes. More than half the drivers (52%) reported at least one hypoglycemia-related driving mishap, 32% reported two or more, and 5% reported six or more. Additionally, almost (41%) said they had experienced disruptive moderate hypoglycemia that impaired driving. Participants using pump therapy to manage their glucose were 35% more likely to record  a hypoglycemia-related fender bender than those using insulin injections.</span></p>
<p style="margin-bottom: 0cm; font-weight: normal;" align="JUSTIFY">
<p style="margin-bottom: 0cm;" align="JUSTIFY"><span style="font-size: small;"><span style="font-weight: normal;">Both results suggest the need for laws that restrict driving in patients with diabetes. Countries that permit people with diabetes to drive (which is most) require that the drivers have no eyesight problems and can document their glycaemic control.</span></span></p>
<p style="margin-bottom: 0cm;" align="JUSTIFY"><span style="font-size: small;"><span style="font-weight: normal;"><br />
</span></span></p>
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		<title>New Mode of Insulin Delivery</title>
		<link>http://www.diabetesendocrinology.in/2010/02/19/new-insulin-delivery/</link>
		<comments>http://www.diabetesendocrinology.in/2010/02/19/new-insulin-delivery/#comments</comments>
		<pubDate>Fri, 19 Feb 2010 04:58:26 +0000</pubDate>
		<dc:creator>arpan</dc:creator>
				<category><![CDATA[New Insulin Delivery]]></category>
		<category><![CDATA[Insulin]]></category>
		<category><![CDATA[new mode of delivery]]></category>

		<guid isPermaLink="false">http://www.diabetesendocrinology.in/?p=566</guid>
		<description><![CDATA[A new way to treat diabetes may be just around the corner. Several biotechnology companies are in hot pursuit of an oral form of insulin. So far, two options exits for patients with diabetes who require insulin – pumps or syringes, with other needle-free options remaining elusive. In 2007, Pfizer, Inc., withdrew Exubera, an inhaled [...]]]></description>
			<content:encoded><![CDATA[<p><!-- 		@page { margin: 2cm } 		P { margin-bottom: 0.21cm } --></p>
<p><!-- 		@page { margin: 2cm } 		P { margin-bottom: 0.21cm } --></p>
<p style="margin-bottom: 0cm;" align="JUSTIFY">
<p style="margin-bottom: 0cm;" align="JUSTIFY"><span style="font-size: small;"><span style="font-weight: normal;">A new way to treat diabetes may be just around the corner. Several biotechnology companies are in hot pursuit of an oral form of insulin. So far, two options exits for patients with diabetes who require insulin – pumps or syringes, with other needle-free options remaining elusive. In 2007, Pfizer, Inc., withdrew Exubera, an inhaled insulin, saying it failed to find favor with doctors and patients. </span></span></p>
<p style="margin-bottom: 0cm; font-weight: normal;" align="JUSTIFY"><span style="font-size: small;">The main hurdle with taking insulin by mouth is the challenge of avoiding digestive action that breaks it down.</span></p>
<p style="margin-bottom: 0cm; font-weight: normal;" align="JUSTIFY"><span style="font-size: small;">Last month, Novo Nordisk started a phase 1 clinical trail in Germany with an oral insulin analog (NN1952). Novo is using Merrion Pharmaceuticals PIc’s GIPET technology to shield insulin from the digestive tract. The trial will investigate the safety and efficacy of NN1952 in healthy volunteers and people with type 1 or type 2 diabetes. The enrollment target is about 80, and results are anticipated in the first half of 2011.</span></p>
<p style="margin-bottom: 0cm;" align="JUSTIFY"><span style="font-size: small;"><span style="font-weight: normal;">Other biotechnology companies like Biocon Ltd as well are in the race to be the first out with an insulin pill. Oramed Pharmaceuticals is currently conducting phase 2B trials of its oral insulin capsule, ORMD-0801.</span></span></p>
<p style="margin-bottom: 0cm;" align="JUSTIFY"><span style="font-size: small;"><span style="font-weight: normal;">Oral Medicine in non-pill form are also in the works. Biodel is developing a sublingual oral insulin formulation called VIA tabTM that dissolves in minutes when placed under the tongue. Generex Biotechnology Corp. is forging ahead with an oral insulin spray, Oral-lynTM.</span></span></p>
<p style="margin-bottom: 0cm;" align="JUSTIFY">
<p style="margin-bottom: 0cm;" align="JUSTIFY"><span style="font-size: small;"><span style="font-weight: normal;"><br />
</span></span></p>
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		<title>Why worry about Diabetes?</title>
		<link>http://www.diabetesendocrinology.in/2009/04/28/why-worry-about-diabetes/</link>
		<comments>http://www.diabetesendocrinology.in/2009/04/28/why-worry-about-diabetes/#comments</comments>
		<pubDate>Tue, 28 Apr 2009 08:58:25 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Why Worry]]></category>
		<category><![CDATA[Diabetes Worry]]></category>
		<category><![CDATA[Poem]]></category>

		<guid isPermaLink="false">http://www.diabetesendocrinology.in/?p=126</guid>
		<description><![CDATA[IF you have Diabetes, Don’t worry and freeze, Careful about your diet Please, Best are grams vegetables &#38; green leaves, Must exercise everyday with ease, Make sure your doctor sees, Your Eyes, Heart, Kidneys and below knees: If you have a problem to cease, Go to Specialist in Diabetes, Your problem just flees, So why [...]]]></description>
			<content:encoded><![CDATA[<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;"><span style="color: #494949;"><span style="font-family: Arial,sans-serif;"><span style="font-size: medium;">IF you have Diabetes,</span></span></span></p>
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;"><span style="color: #494949;"><span style="font-family: Arial,sans-serif;"><span style="font-size: medium;">Don’t worry and freeze,</span></span></span></p>
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;"><span style="color: #494949;"><span style="font-family: Arial,sans-serif;"><span style="font-size: medium;">Careful about your diet Please,</span></span></span></p>
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;"><span style="color: #494949;"><span style="font-family: Arial,sans-serif;"><span style="font-size: medium;">Best are grams vegetables &amp; green leaves,</span></span></span></p>
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;"><span style="color: #494949;"><span style="font-family: Arial,sans-serif;"><span style="font-size: medium;">Must exercise everyday with ease,</span></span></span></p>
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;"><span style="color: #494949;"><span style="font-family: Arial,sans-serif;"><span style="font-size: medium;">Make sure your doctor sees,</span></span></span></p>
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;"><span style="color: #494949;"><span style="font-family: Arial,sans-serif;"><span style="font-size: medium;">Your Eyes, Heart, Kidneys and below knees:</span></span></span></p>
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;"><span style="color: #494949;"><span style="font-family: Arial,sans-serif;"><span style="font-size: medium;">If you have a problem to cease,</span></span></span></p>
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;"><span style="color: #494949;"><span style="font-family: Arial,sans-serif;"><span style="font-size: medium;">Go to Specialist in Diabetes,</span></span></span></p>
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;"><span style="color: #494949;"><span style="font-family: Arial,sans-serif;"><span style="font-size: medium;">Your problem just flees,</span></span></span></p>
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;"><span style="color: #494949;"><span style="font-family: Arial,sans-serif;"><span style="font-size: medium;">So why worry about Diabetes.</span></span></span></p>
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;">
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;" align="center"><span style="color: #494949;"><span style="font-family: Arial,sans-serif;"><span style="font-size: medium;"><em>Dr Enoch Sundaram</em></span></span></span></p>
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		<title>Diabetes, why me?</title>
		<link>http://www.diabetesendocrinology.in/2009/04/28/why-do-i-have-diabetes/</link>
		<comments>http://www.diabetesendocrinology.in/2009/04/28/why-do-i-have-diabetes/#comments</comments>
		<pubDate>Tue, 28 Apr 2009 07:29:30 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Diabetes why me?]]></category>
		<category><![CDATA[Diabetes]]></category>
		<category><![CDATA[why me? Guilt]]></category>

		<guid isPermaLink="false">http://www.diabetesendocrinology.in/?p=122</guid>
		<description><![CDATA[DIABETES – You have heard about it often, now know about it, but when you have to face it yourselves, it is difficult. You ask why me, what I have done wrong? Important is to remember that it is no fault of yours that you have Diabetes. It is the single most important metabolic disease [...]]]></description>
			<content:encoded><![CDATA[<p style="text-indent: 1.27cm; margin-bottom: 0cm;" align="center">
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;" align="justify">DIABETES – You have heard about it often, now know about it, but when you have to face it yourselves, it is difficult. You ask why me, what I have done wrong? Important is to remember that it is no fault of yours that you have Diabetes. It is the single most important metabolic disease that can affect nearly every organ system in the body. There are 190 million diabetics in the world now. Indians are genetically more susceptible (India has been labeled as Diabetes capital of the world) and the World Health Organization predicts the number of diabetics in India would go up to 40 million by 2010 and 74 million by 2025. See – you are not alone! Now, let us face the truth together.</p>
<p style="margin-bottom: 0cm;" align="justify">There was a school of thought that “ignorance is bliss”, knowledge of illness causes distress and prevents or reduces hope. Days have gone, now the challenge is to move away from this and to be a mature person who is capable of accepting the responsibility of treating his own illness. The whole idea is to<span style="font-size: x-large;"> </span>understand that treatment will be beneficial and delaying treatment will lead to undesirable consequences.</p>
<p style="margin-bottom: 0cm;" align="justify">
<p style="margin-bottom: 0cm;" align="justify">Different types of patient responses that have been seen with Diabetes as an illness</p>
<ul>
<li>
<p style="margin-bottom: 0cm;" align="justify">Knowledgeable &#8211; 	Whoever knows the impact of his illness is willing to continue with 	right treatment and has his full family support. He is calm and 	composed about his illness</p>
</li>
<li>
<p style="margin-bottom: 0cm;" align="justify">Scared &#8211; Whoever 	fears his illness, resents the rigid lifestyle, with low family 	support and is dependent on others</p>
</li>
<li>
<p style="margin-bottom: 0cm;" align="justify">Casual &#8211; Whoever is 	nonchalant about his illness and does not want to take action till 	complications set in)</p>
</li>
<li>
<p style="margin-bottom: 0cm;" align="justify">Myopic &#8211; Whoever 	wants maximum results with minimum input and has minimum awareness 	of the illness.</p>
</li>
<li>
<p style="margin-bottom: 0cm;" align="justify">Know it all &#8211; 	Whoever fakes he has all the knowledge about the disease, but seldom 	has. A little knowledge is a dangerous thing!</p>
</li>
</ul>
<p style="margin-bottom: 0cm;" align="justify">We want to give you all information in a clear language so that you can understand the problem and take an active part in solving it. At the same time you need to be aware the new things are happening in this field.</p>
<p style="margin-bottom: 0cm;" align="justify">
<p style="margin-bottom: 0cm;" align="justify">Not uncommonly, the first response in knowing a chronic illness is Denial and Diabetes is o exception. Reactions to news about chronic illness vary from person to person. They include disbelief, revolt (accusation), depression (sadness for health lost), confronting reality and consenting (coping) with serenity. These are integrating processes. The process of integration is also dependent on how the patient views his or her disease. Hence patient education plays a very important role.</p>
<p style="margin-bottom: 0cm;" align="justify">
<p style="margin-bottom: 0cm;" align="justify">A young lady had a blood sugar test which revealed that she was suffering from Diabetes Mellitus. She just could not come to terms with this and went through a myriad of emotions, finally leading to denial. She refused treatment, saying that she just did not have Diabetes. A suitable approach would be to acknowledge the denial and to seek reasons for it. She could be asked the reasons for her denial which would evoke a response, which could be addressed suitably. Should the denial continue with the patient saying that she just does not believe it, one could proceed by gently placing before her the consequences of her denial. On gently persisting, issues that can be handled will come out and the denial broken successfully.</p>
<p style="margin-bottom: 0cm;" align="justify">
<p style="margin-bottom: 0cm;" align="justify">Look at another extreme example. A young man, a juvenile diabetic, decides to tie the knot, but fearing that his young bride would reject him if she knew his medical condition, keeps her in the dark. The marriage is over and off they go for their honeymoon. No insulin is possible and the young man lands into complications of high sugar Diabetic coma on return after three days. He promptly gets himself into the nursing home of the doctor who has been treating him, pleading that the doctor announces that diabetes was just detected! What does the doctor do?</p>
<p style="margin-bottom: 0cm;" align="justify">
<p style="margin-bottom: 0cm;" align="justify">Art of communication as an important part of therapy; occasionally it is the only constituent. It usually requires greater thought and planning than a drug prescription, and unfortunately it is commonly administered in sub therapeutic doses! Nothing can be farther than the truth and acceptance of reality lies in the manner in which it is disclosed. This responsibility lies with the health care provider. Various steps in helping patients cope with Diabetes would help them accept the diagnosis, give information that is required, scope for ventilation of feelings, formulate an action plan and be available for the patient.</p>
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;" align="justify">Researchers are intensively studying the genetic and environmental factors that underlie the susceptibility to obesity, pre-diabetes and diabetes. As they learn more about the molecular events that lead to diabetes, they will develop ways to prevent and cure the different stages of this disease. Until then, we can hope to prevent further progression of this pandemic by eating healthy and having an exercise filled healthier lifestyle. Yes, you may be at risk. But you can surely postpone it.  The doctor is a friend, not a dictator in sharing the treatment responsibility and should make the patient “knowledgeable”.  Let’s tackle Diabetes hand in hand!</p>
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		<title>A different Diabetes in Childhood, deviation from tradition!</title>
		<link>http://www.diabetesendocrinology.in/2009/04/28/type-2-diabetes-in-children/</link>
		<comments>http://www.diabetesendocrinology.in/2009/04/28/type-2-diabetes-in-children/#comments</comments>
		<pubDate>Tue, 28 Apr 2009 07:23:03 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Type 2 Diabetes in Children]]></category>
		<category><![CDATA[Childhood Diabetes]]></category>
		<category><![CDATA[Type 2 Diabetes]]></category>

		<guid isPermaLink="false">http://www.diabetesendocrinology.in/?p=118</guid>
		<description><![CDATA[Childhood Diabetes Mellitus is traditionally called Type1 Diabetes or Juvenile Diabetes where pancreas fails to produce the key enzyme Insulin, as a result the child becomes dependent on Insulin for whole of his/her life. We all know the incidence of Diabetes is increasing very rapidly all over the world but fortunately we do not have [...]]]></description>
			<content:encoded><![CDATA[<p class="western">Childhood Diabetes Mellitus is traditionally called Type1 Diabetes or Juvenile Diabetes where pancreas fails to produce the key enzyme Insulin, as a result the child becomes dependent on Insulin for whole of his/her life. We all know the incidence of Diabetes is increasing very rapidly all over the world but fortunately we do not have much cases of type 1 Diabetes in our country as opposed to the west.</p>
<p class="western" style="font-weight: normal;" align="justify"><span style="font-size: small;">The problem in our country is the adult type of Diabetes, so called type 2 Diabetes where body does produce Insulin but the insulin is either less in amount or lacks quality or both. We use diet and tablets to make the Insulin work better, at least in the initial stage. This is the type of Diabetes which is increasing in India in epidemic proportion, so much so that India has been labelled as the diabetic capital of the world. Far worse news is that we are getting Diabetes at least 10 years earlier as our counterparts in the west. </span></p>
<p class="western" style="font-weight: normal;" align="justify"><span style="font-size: small;">Modernisation, lack of exercise, easy availability and palatability (!) of fast food all are to share the responsibility along with the change of the environmental pollution etc. In India, 15-20 % of people living in cities aged 20 years+ have Diabetes as opposed to 4-5 % in the villages. This so called “TV and Couch syndrome” is catching our children and that is the worst we can think of. Older children and adolescents are fond of fast food, watching TV and physical inactivity. Typically the child is obese and has family history of type 2 Diabetes (they are born with the gene). They may have peripheral marker of Insulin resistance called Acanthosis Nigricans (a blackish appearance in the skin fold areas). We do not know exactly what is the percentage of type 2 Diabetes in childhood and adolescence as there is no population based study yet available in our country but we are seeing this more and more in our day-to-day clinical practice. </span></p>
<p class="western" style="font-weight: normal;" align="justify"><span style="font-size: small;">We need to do a lot better to prevent this and at the same time to treat the affected. Not only concentrating on the patient, we need to educate families as almost all have positive family history of type 2 Diabetes. We need to create awareness of this type of Diabetes in young among health care providers (be it general Practitioner, Physician, Paediatrician, nurse), governmental and non-governmental agencies involved in health care, pharmaceutical companies and charitable  foundations. </span></p>
<p class="western" style="font-weight: normal;" align="justify"><span style="font-size: small;">Till today our knowledge is limited, we do not know what is the best way to treat this group, but as we see Insulin may not be required from the day 1 of the diagnosis unlike juvenile or type 1 Diabetes where Insulin is a must. We need good quality research to explore the problem, its’ pathogenesis, prevention and treatment. As Bangalorean, we are proud to be a part of multinational multicentric research study to find out the best treatment option of type 2 Diabetes in childhood and adolescence.</span></p>
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		<title>Type 1 Diabetes</title>
		<link>http://www.diabetesendocrinology.in/2009/04/28/type-1-diabetes/</link>
		<comments>http://www.diabetesendocrinology.in/2009/04/28/type-1-diabetes/#comments</comments>
		<pubDate>Tue, 28 Apr 2009 07:19:02 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Type 1 Diabetes in Children]]></category>
		<category><![CDATA[Childhood Diabetes]]></category>
		<category><![CDATA[type 1 Diabetes]]></category>

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		<description><![CDATA[What are the types of Diabetes in childhood? Childhood Diabetes is of 2 types. Type 1 is insulin dependent and type 2 is due to defective insulin action. Why my child? It is unfortunate it is your child. The cause of diabetes is not fully understood. Diabetes is most often associated with a genetically determined [...]]]></description>
			<content:encoded><![CDATA[<p style="margin-bottom: 0cm;" align="justify"><strong>What are the types of Diabetes in childhood?</strong></p>
<p style="margin-bottom: 0cm;" align="justify">Childhood Diabetes is of 2 types. Type 1 is insulin dependent and type 2 is due to defective insulin action.</p>
<p style="margin-bottom: 0cm;" align="justify"><strong>Why my child?</strong></p>
<p style="margin-bottom: 0cm;" align="justify">It is unfortunate it is your child. The cause of diabetes is not fully understood. Diabetes is most often associated with a genetically determined predisposition, the presence of autoimmunity and environmental influence.</p>
<p style="margin-bottom: 0cm;" align="justify"><strong>Is Insulin a must?</strong></p>
<p style="margin-bottom: 0cm;" align="justify">Yes. Insulin is a must for Type 1 diabetes as their body is deficient of insulin. If insulin is not given the child can progress to diabetic coma.</p>
<p style="margin-bottom: 0cm;" align="justify"><strong>When my child should start injecting?</strong></p>
<p style="margin-bottom: 0cm;" align="justify">Insulin treatment should be started as soon as the diagnosis is done to prevent the metabolic disturbances and diabetic coma. From around the age of 8 years your child is expected to inject him- or her-self.</p>
<p style="margin-bottom: 0cm;" align="justify"><strong>What special monitoring is required?</strong></p>
<p style="margin-bottom: 0cm;" align="justify">Self -monitoring of blood glucose (SMBG) with a glucometer is an essential tool in the management of childhood diabetes. This will help in good monitoring of blood sugar, detects hypoglycaemia (low sugar), and helps in safe management of hyperglycaemia.</p>
<p style="margin-bottom: 0cm;" align="justify">
<p style="margin-bottom: 0cm;" align="justify"><strong>What to do in the school?</strong></p>
<p style="margin-bottom: 0cm;" align="justify">School is not at all a problem. They should be treated as a normal child but care to be taken about meal and snack timings and education about recognition and treatment of hypoglycaemia to the teachers and caretakers should be given.</p>
<p style="margin-bottom: 0cm;" align="justify"><strong>What about parties?</strong></p>
<p style="margin-bottom: 0cm;" align="justify">Children should not be restricted from parties, but too much is too bad. Occasional parties are allowed but take care to inform the host about diabetic child and make arrangements for diabetic sweets.</p>
<p style="margin-bottom: 0cm;" align="justify"><strong>What about marriage?</strong></p>
<p style="margin-bottom: 0cm;" align="justify">Diabetic patients can get married as any other individual.</p>
<p style="margin-bottom: 0cm;" align="justify"><strong>Will it be all right for her to become pregnant?</strong></p>
<p style="margin-bottom: 0cm;" align="justify">Pregnancy is not contraindicated to diabetic patients. Care should be taken regarding good glucose control of the mother and close monitoring of baby’s growth through out pregnancy</p>
<p style="margin-bottom: 0cm;" align="justify"><strong>Will she pass on diabetes to the baby?</strong></p>
<p style="margin-bottom: 0cm;" align="justify">When a member of the family has diabetes there is a risk to relatives of developing the disease. And it is as follows</p>
<p style="margin-left: 1.27cm; text-indent: 1.27cm; margin-bottom: 0cm;" align="justify">-risk to child of a father with type 1 diabetes –7%</p>
<p style="margin-left: 1.27cm; text-indent: 1.27cm; margin-bottom: 0cm;" align="justify">-risk to child of a mother with type 1 diabetes- 2%</p>
<p style="margin-left: 1.27cm; text-indent: 1.27cm; margin-bottom: 0cm;" align="justify">-risk to identical twin of a child  with type 1 diabetes- 35%</p>
<p style="margin-left: 1.27cm; text-indent: 1.27cm; margin-bottom: 0cm;" align="justify">-risk to sibling of a child with type 1 diabetes- 3-6%</p>
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		<title>Hope for Diabetes</title>
		<link>http://www.diabetesendocrinology.in/2009/04/28/hope-stemcell/</link>
		<comments>http://www.diabetesendocrinology.in/2009/04/28/hope-stemcell/#comments</comments>
		<pubDate>Tue, 28 Apr 2009 07:14:14 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[A New Hope For Diabetes]]></category>
		<category><![CDATA[DPPIV inhibitors]]></category>
		<category><![CDATA[Stem cell therapy]]></category>

		<guid isPermaLink="false">http://www.diabetesendocrinology.in/?p=111</guid>
		<description><![CDATA[Treatment Options for people with Diabetes While Insulin is a must for type 1 Diabetes, type 2 Diabetes is THE problem us (more than 98% of all people with Diabetes), a standard treatment plan for which includes diet &#38; exercise, tablets and Insulin. Despite progress in understanding of the underlying disease mechanisms for diabetes, there [...]]]></description>
			<content:encoded><![CDATA[<p style="margin-bottom: 0cm;" align="justify">
<p style="margin-bottom: 0cm;" align="justify"><strong>Treatment Options for people with Diabetes</strong></p>
<p style="margin-bottom: 0cm;" align="justify">While Insulin is a must for type 1 Diabetes, type 2 Diabetes is THE problem us (more than 98% of all people with Diabetes), a standard treatment plan for which includes diet &amp; exercise, tablets and Insulin. <em><span style="font-style: normal;">Despite progress in understanding of the underlying disease mechanisms for diabetes, there is still a paucity of effective therapies</span></em>. Unfortunately till today we do not have a perfect Diabetes tablet or another way to take Insulin other than the injection.</p>
<p style="margin-bottom: 0cm;" align="justify"><strong>RAYS OF HOPE !!!</strong></p>
<p style="margin-bottom: 0cm;" align="justify">Researchers have stumbled upon various new modalities of treatment for Diabetes. They include</p>
<ul>
<li>
<p style="margin-bottom: 0cm;" align="justify">Inhaled insulin</p>
</li>
<li>
<p style="margin-bottom: 0cm;" align="justify">New tablets</p>
<ul>
<li>
<p style="margin-bottom: 0cm;" align="justify">DPP IV inhibitors</p>
</li>
<li>
<p style="margin-bottom: 0cm;" align="justify">Sodium glucose 		transport inhibitors</p>
</li>
</ul>
</li>
<li>
<p style="margin-bottom: 0cm;" align="justify">Pancreatic 	transplant</p>
</li>
<li>
<p style="margin-bottom: 0cm;" align="justify">Stem cell therapy 	for diabetes</p>
</li>
</ul>
<p style="margin-bottom: 0cm;" align="justify">
<p style="margin-bottom: 0cm;" align="justify"><strong>Inhaled Insulin</strong></p>
<p style="margin-bottom: 0cm;" align="justify">Here is Insulin is delivered directly to the lungs by an inhaler akin to those used by people with Asthma. This only can work for 3-4 hours, so the long acting insulin has to be still taken as an injection. Te absorption depends on various factors like presence of flu, nasal allergy, asthma, chronic bronchitis, etc.</p>
<p style="margin-bottom: 0cm;" align="justify"><strong>DPP IV Inhibitors</strong></p>
<p style="margin-bottom: 0cm;" align="justify"><span style="color: #000000;">This group of medication works increasing the blood Insulin, because it inhibits the enzyme called Dipeptidyl peptidase (DPP)-IV which normally degrades Insulin. inhibitors are a promising new approach to Type 2 diabetes that function as indirect stimulators of insulin secretion.</span> They may be available as tablet or injection, one tablet has been launched in US, going to be available in our country soon. One form of injection is available with us here recently.</p>
<p style="margin-bottom: 0cm;" align="justify">The beauty of this group of medicine is that they are less likely to cause low sugar because they inhibit the enzyme when sugar is high but not when normal.</p>
<p style="margin-bottom: 0cm;"><span style="color: #000000;"><strong>Sodium glucose transport inhibitors</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify"><span style="color: #000000;">This unique group of medicine is different from all others as they spill extra sugar from the blood to urine when blood sugar goes above a certain level. Researches are ongoing with this molecule.</span></p>
<p style="margin-bottom: 0cm;"><span style="color: #000000;"><strong>Pancreatic transplant<br />
</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify">This is a treatment option mainly for people going for Kidney transplant when a portion of the Pancreas of the donor is taken and implanted, in that way same medicine to prevent rejection can be used to protect the transplanted pancreas. If only the part of the pancreases is transplanted t<span style="color: #414141;">he side effects of the chemotherapy are much more detrimental than Diabetes and this does not offer any guarantee. </span></p>
<p style="margin-bottom: 0cm;" align="justify"><span style="color: #000000;"><strong>Stem cell therapy for Diabetes</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify"><span style="color: #000000;">Human beings are made from one cell in the beginning of the development; the cell multiplies and they take individual responsibilities. So initial rows of ells are unspecialized cells, later when they take up individual responsibilities they are called specialized cells. Unspecialized cells are called </span>Stem cells. The two broad categories of human stem cells are (a) Embryonic stem cells, derived from aborted fetal tissue and (b) Adult stem cells that are found in adult tissues. There is a lot of Ethical, Moral, Legal and scientific issues are there in embryonic stem cell therapy knowing the fact very well that this type is better suited for the job.</p>
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;" align="justify"><span style="color: #000000;">To treat diabetes, stem cells need to be cultivated into insulin-producing cells. Once that has been accomplished, researchers plan to transplant stem cells that have been cultivated into insulin-producing cells into diabetic patients. Currently, those who receive transplants must take drugs that suppress the body’s immune system. If a person’s own stem cells could be cultivated and used for transplant, such drugs would not be needed. </span></p>
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;" align="justify"><span style="color: #ffffff;"><span style="color: #000000;"><span lang="en">Before any cell-based therapy to treat diabetes makes it to the clinic, many safety issues must be addressed.  A major considerat</span></span><span style="color: #000000;"><span lang="en">ion is whether transplanted stem cells can grow uncontrolled and induce the formation of tumors.</span></span></span></p>
<p style="margin-top: 0.49cm; margin-bottom: 0.49cm;" align="justify"><span style="color: #ffffff;"><span style="color: #000000;"><span lang="en"><br />
</span></span></span></p>
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		<title>Diabetes and Pregnancy</title>
		<link>http://www.diabetesendocrinology.in/2009/04/28/pregnancy/</link>
		<comments>http://www.diabetesendocrinology.in/2009/04/28/pregnancy/#comments</comments>
		<pubDate>Tue, 28 Apr 2009 07:06:40 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Diabetes and Pregnancy]]></category>
		<category><![CDATA[GTT]]></category>
		<category><![CDATA[Insulin]]></category>

		<guid isPermaLink="false">http://www.diabetesendocrinology.in/?p=104</guid>
		<description><![CDATA[What are the types of Diabetes in Pregnancy? Pregnancy Diabetes is a very important area, which needs special attention and very close supervision both by Obstetrician and Diabetes physician. Diabetic pregnancies are mainly of two types. First one is women with known diabetes either type 1 or 2 becoming pregnant called pre-gestational Diabetes. The other [...]]]></description>
			<content:encoded><![CDATA[<p style="margin-bottom: 0cm;" align="center">
<p style="margin-bottom: 0cm;" align="justify"><span style="font-size: medium;"><strong>What are the types of Diabetes in Pregnancy?</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify">Pregnancy Diabetes is a very important area, which needs special attention and very close supervision both by Obstetrician and Diabetes physician. Diabetic pregnancies are mainly of two types. First one is women with known diabetes either type 1 or 2 becoming pregnant called pre-gestational Diabetes. The other is diabetes for the first time detected in the current pregnancy what is called Gestational Diabetes. Your Obstetrician will check this as part of routine antenatal check up. Most of the cases you do not require insulin after delivery. Your blood sugar should be checked 6 weeks after delivery (GTT) to make sure that Diabetes has disappeared.</p>
<p style="margin-bottom: 0cm;" align="justify"><span style="font-size: medium;"><strong>Who are at risk of developing Diabetes in Pregnancy?</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify">Any of the following conditions can be a risk for developing diabetes in pregnancy: obesity, family history of diabetes, high blood pressure, birth of big baby in the last pregnancy, pregnancy after 35 years of age, history of unexplained loss of baby in uterus before. This high risk women should be carefully looked for diabetes by frequent monitoring rather than waiting for symptoms of diabetes to appear.</p>
<p style="margin-bottom: 0cm;" align="justify"><span style="font-size: medium;"><strong>Why is it important to treat Diabetes in Pregnancy?</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify">It is important to treat Diabetes in pregnancy for a safe confinement. Some potential risks to the foetus if sugars are uncontrolled include:</p>
<ul>
<li>
<p style="margin-top: 0.49cm; margin-bottom: 0cm;"><span style="color: #000000;">The 	baby’s body is larger than normal—called </span><strong><span style="color: #000000;">macrosomia</span></strong><span style="color: #000000;">.  	A large baby may need to be delivered by cesarean section, instead 	of naturally through the vagina. </span></p>
</li>
<li>
<p style="margin-bottom: 0cm;"><span style="color: #000000;">The baby’s 	blood sugar is too low—called </span><strong><span style="color: #000000;">hypoglycemia</span></strong><span style="color: #000000;">.  	Starting to breastfeed right away can help get more glucose to the 	baby.  The baby may also need to get glucose through a tube 	into his or her blood. </span></p>
</li>
<li>
<p style="margin-bottom: 0cm;"><span style="color: #000000;">The baby’s 	skin turns yellowish and the whites of the eyes may change 	color—called </span><strong><span style="color: #000000;">jaundice</span></strong><span style="color: #000000;">.  	This condition is easily treated and is not serious if treated. </span></p>
</li>
<li>
<p style="margin-bottom: 0cm;"><span style="color: #000000;">The baby may 	have trouble breathing and need oxygen or other help—called </span><strong><span style="color: #000000;">Respiratory Distress Syndrome</span></strong><span style="color: #000000;">. </span></p>
</li>
<li>
<p style="margin-bottom: 0.49cm;"><span style="color: #000000;">The baby 	may have low mineral levels in the blood.  This problem can 	causes muscle twitching or cramping, but can be treated by giving 	the baby extra minerals</span></p>
</li>
</ul>
<p style="margin-bottom: 0cm;" align="justify"><span style="font-size: medium;"><strong>Why pregnancy Diabetes is different from Diabetes in other time?</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify">This is one situation where we strongly recommend controlling diabetes very strictly with particular emphasis on postprandial sugar checking (two hours after food). Also it is very important to remember that dose requirement of Insulin in pregnancy always increase as the baby grows bigger. This is because placenta increases in size through out the pregnancy to keep the baby well. Placenta secretes some hormones which works against Insulin. If the dose of Insulin does not increase we feel worried with the function of the placenta.</p>
<p style="margin-bottom: 0cm;" align="justify"><span style="font-size: medium;"><strong>Is the diet different in Pregnancy?</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify">As the demand is more the calorie intake should be more in pregnancy. In average an increase of 500 calorie is advised. If you are overweight then there is no need to increase this, also you should not try to diet strictly or loose weight. It is better to see a professional dietitian at the time of diagnosis. Three meal and three snack regimen is very much indicated in pregnancy.</p>
<p style="margin-bottom: 0cm;" align="justify"><span style="font-size: medium;"><strong>Why can not I use tablet for Diabetes in pregnancy?</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify">Tablets available for treatment of Diabetes cross the placenta. We do not give tablet in pregnancy with the fear that baby’s blood sugar may drop. Also tablets take long time to work and we need to change the treatment in pregnancy very frequently, so tablets are not good.</p>
<p style="margin-bottom: 0cm;" align="justify"><span style="font-size: medium;"><strong>What is the best way of monitoring Diabetes in Pregnancy?</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify">In pregnancy we strongly recommend using glucometer, so that control will be there in your hand. It is important to remember that we check all postprandial sugar, rather than checking only after breakfast, as is the common practice. HbA<sub>1</sub>C checking can be of some value to keep an eye on average control.</p>
<p style="margin-bottom: 0cm;" align="justify"><span style="font-size: medium;"><strong>How often to monitor sugar in pregnancy?</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify">It is important that we keep a close eye on the sugar in pregnancy. Normally in pregnancy we prefer monitoring fasting and 2-hr after meal sugars i.e., fasting, 2 hrs after breakfast, 2 hrs after lunch and 2 hrs after dinner. This set; we would prefer should be done twice a week 2-3 days apart.</p>
<p style="margin-bottom: 0cm;" align="justify">
<table dir="ltr" border="1" cellspacing="0" cellpadding="7" width="525" bordercolor="#000000">
<col width="87"></col>
<col width="146"></col>
<col width="117"></col>
<col width="117"></col>
<tbody>
<tr valign="top">
<td width="87" height="3">
<p align="justify"><strong>Fasting</strong></p>
</td>
<td width="146">
<p align="justify"><strong>2-hr after breakfast</strong></p>
</td>
<td width="117">
<p align="justify"><strong>2-hr after lunch</strong></p>
</td>
<td width="117">
<p align="justify"><strong>2-hr after dinner</strong></p>
</td>
</tr>
</tbody>
</table>
<p style="margin-bottom: 0cm;" align="justify"><span style="font-size: medium;"><strong>What is the sugar control to be achieved in pregnancy?</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify">In pregnancy the targets are much stricter. We want fasting sugar &lt;90mg/dl, but surely &lt;100mg/dl and 2 hr value &lt;125mg/dl, but surely &lt;140mg/dl.</p>
<p style="margin-bottom: 0cm;" align="justify"><span style="font-size: medium;"><strong>Why my Insulin dose is changing every time?</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify">This is very important to understand. As pregnancy advances, particularly from after 28 weeks, placental activity increases to keep the baby in good health. To do this placenta produces some hormones which act against Insulin and your dose of Insulin goes up and up, sometimes on daily basis we need to increase Insulin dose.</p>
<p style="margin-bottom: 0cm;" align="justify">So, increment of Insulin dose in pregnancy is normal, if the dose does not go up, we get worried whether the placenta is working normally or not.</p>
<p style="margin-bottom: 0cm;" align="justify"><span style="font-size: medium;"><strong>What exercise is good in Pregnancy?</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify">Standard antenatal exercise should be fine from sugar point as well. Walking would be the best and weight lifting or strainous exercise should be avoided. Swimming is also a very good exercise.</p>
<p style="margin-bottom: 0cm;" align="justify"><span style="font-size: medium;"><strong>What extra care needed during delivery?</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify">At the time of delivery, a normal or near normal sugar is very important. Most of the time during delivery you will not be eating, particularly if the delivery is by section. So we commonly connect you to a glucose drip (to give you nutrition) with Insulin. At this time for a strict control we check blood sugar by pricking finger frequently, sometimes once in every hour. In case of gestational diabetes we disconnect Insulin soon after delivery of the placenta. If you had diabetes from before your dose of Insulin reduced to that before pregnancy. If you were on tablet before, you should continue Insulin till the time you are breast feeding.</p>
<p style="margin-bottom: 0cm;" align="justify"><span style="font-size: medium;"><strong>What happens to the sugar of my baby?</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify">The baby’s sugar is usually normal. If at the time of delivery, the mothers sugars are not under control, then there is a chance that the baby’s sugar can be on the lower side. Early initiation of breast feeding after delivery is advised.</p>
<p style="margin-bottom: 0cm;" align="justify"><span style="font-size: medium;"><strong>What follow up is required?</strong></span></p>
<p style="margin-bottom: 0cm;" align="justify">People with gestational diabetes should get glucose tolerance test 6 weeks after delivery to make sure that diabetes is disappeared. You must remember that you will have a high risk of diabetes in future, so take precaution. Eat healthy food, take some form of regular exercise and do not become fat.</p>
<p style="margin-bottom: 0cm;" align="justify">Follow up for people with type 1 or 2 diabetes would be the same as in non-pregnant time. If you are planning to conceive again, make sure your control at the time of conception is very good and you take Folic acid vitamin 5 gm every day.</p>
<p style="margin-bottom: 0cm;" align="justify">
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